how Progesterone effects women with endometriosis?
Progesterone is a natural steroid hormone that is found in much higher concentrations in women than men. In women, it operates harmoniously with estrogen and other steroid hormones involved in physiological functions such as the menstrual cycle and preparing the uterine lining for implantation by a fertilized egg. Other essential roles of progesterone include building new bone tissue and countering the tendency of estrogen to cause excess growth in the lining of the uterus, which can lead to endometriosis.
8 tips how to use progesterone cream correctly
1. Where are the best places to use NPC?
- Upper Chest
- Inner arms
- Palms of hands and feet
2. Is it normal that the symptoms become worse at the beginning?
when first beginning natural progesterone cream. When first introducing progesterone back into the body after an extended period of progesterone deficiency, the estrogen receptor sites ‘wake up’ (are stimulated), enhancing the action of estrogen for a short period of time, but should level out and go away over the next couple of cycles, as progesterone levels increase.
3. Stress affects progesterone levels. How?
Stress increases cortisol levels. Cortisol competes for progesterone receptors; the higher the stress the more cortisol the body produces. This means that those receptor sites may be occupied by cortisol rather than progesterone, which may require temporary increase in progesterone supplementation. If you are not managing your stress levels, the natural progesterone cream you are currently using may not be effective because of elevated cortisol levels. Make stress reduction part of your plan to balance hormone levels.
4. How long does it take to feel the effect?
Severe progesterone deficiency requires more time to increase progesterone levels with progesterone cream supplementation. It takes anywhere from 4-12 months to bring progesterone levels back up in women with very low progesterone levels. Following a loading dose protocol may help to bring the levels up quicker, but consistency of use over an extended period of time is best. For women who are trying to conceive, a realistic plan is going to help achieve pregnancy and prevent miscarriage due to progesterone deficiency. Give yourself many months of progesterone cream supplementation before even trying for a baby, to help prevent the likelihood of miscarriage.
5. Split dosage up between morning and nighttime application
Apply the cream once in the morning and once in the evening before bed. Using it before bedtime may help some people to sleep better. Splitting the dosage up ensures 8-12 hours of sustained delivery. If you apply it all at one time, only once a day, it will still only last 8-12 hours, leaving the other 12 hours where you are not receiving any. The split dosage ensures optimum progesterone levels are maintained.
6. Each cycle, stop using natural progesterone cream
only when you have confirmed you are NOT pregnant. This means if you are trying to get pregnant while using NPC, be sure to continue it until you have definitely confirmed you are not pregnant. If you get a positive pregnancy test result, continue on with the progesterone cream. Be sure not to skip a day of use of NPC in pregnancy. Doing so may result in a sudden drop of progesterone levels, which may cause a miscarriage. Have two bottles on hand at all times to ensure you don’t run out.
7. Which is the best way to stop using npc?
When you decide it is time to stop supplementing with natural progesterone cream, simply reduce the amount you use each time you apply it. Do this on the last cycle you plan on using it. If you are pregnant, do not do this until at least the 16th week of gestation, when the placenta takes over progesterone production.
8. When should I avoid using NPC?
There are certain health conditions in which natural progesterone cream supplementation should be avoided. If you have a history of gestational pemphigoid (dermatosis of pregnancy), jaundice of pregnancy, severe active liver disease, hepatitis, rotor syndrome, Dubin-Johnson syndrome, or unexplained/abnormal vaginal bleeding you should not use natural progesterone cream.(1)
Synthetic Progestins such as Megestrol and Provera compete with the receptor/binding sites normally reserved for Progesterone. Progesterone taken together with these synthetic hormones will not work. You are advised to withdraw from using synthetic Progestins gradually before starting to use Natural Progesterone for treatment of Endometriosis.